Organocatalytic dynamic kinetic resolution of azlactones to construct chiral N-acyl amino acid oxime esters.
نویسندگان
چکیده
A direct strategy to obtain N-acyl amino acid oxime esters has been developed through the dynamic kinetic resolution of azlactones with oximes. In the presence of a chiral bisguanidinium salt catalyst, a variety of chiral N-acyl amino acid oxime esters were generated in excellent enantiomeric excesses (up to 97%) and high yields (up to 99%). The active oxime esters could be used in dipeptide synthesis.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 80 شماره
صفحات -
تاریخ انتشار 2015